VIP 5MG

  VIP

VIP is a 28–amino acid neuropeptide, part of the secretin/glucagon family.

Naturally produced in the gut, pancreas, and brain, especially in the hypothalamus and enteric nervous system.

Potential Benefits of VIP (Research-Based)

1. Neuroprotection & Brain Health

Enhances neuronal survival and protects against excitotoxic damage

Regulates circadian rhythm and sleep-wake cycles

May improve memory and cognitive resilience

2. Immune Modulation

Suppresses excessive inflammation and autoimmunity

Enhances tolerance and regulatory T-cell activity

Being explored for autoimmune conditions (RA, IBD, MS)

3. Anti-Inflammatory & Healing

Protects mucosal barriers (gut, lungs)

Reduces oxidative stress and tissue injury

May accelerate wound healing and tissue repair

4. Cardiovascular & Pulmonary Support

Potent vasodilator → improves circulation and reduces vascular resistance

Pulmonary benefits: bronchodilation, improved oxygenation

Studied for pulmonary hypertension and asthma

5. Gastrointestinal Function

Stimulates intestinal secretion and motility

Protects gut lining integrity

Potential applications in IBS, IBD, and leaky gut

Key Caveats

Short Half-Life: Native VIP degrades quickly in circulation; analogs or formulations are often required for stability.

Potency: Works at very low concentrations; improper dosing can cause GI upset or hypotension.

Limited Human Trials: Most clinical use remains experimental (except a few orphan-drug studies, e.g., Aviptadil for pulmonary hypertension and COVID-related ARDS).

Systemic Effects: Because it is a vasodilator and gut motility stimulator, side effects may include flushing, loose stools, or low blood pressure.

In summary: VIP is a multifunctional neuropeptide that regulates inflammation, immunity, vasodilation, and neuroprotection. Its therapeutic promise spans autoimmunity, pulmonary disease, gut health, and neurodegeneration, though stability and delivery remain key challenges.