MELANOTAN 1

Melanotan 1 (Afamelanotide) — often called “the tanning peptide” — is a synthetic analog of the natural hormone alpha-melanocyte-stimulating hormone (α-MSH). It was originally developed for photoprotection and pigmentation disorders, not purely for cosmetic tanning.
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⚗️ What It Is
Chemical nature: Synthetic linear peptide analog of α-MSH.
Mechanism: Activates the melanocortin-1 receptor (MC1R) on skin melanocytes, which increases melanin production (skin pigment).
Form: Typically a lyophilized powder used for research, and clinically as Afamelanotide implants under the trade name Scenesse® in Europe and the U.S. (FDA-approved for erythropoietic protoporphyria).
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🌞 Potential Benefits (Research-Based)
Benefit Mechanism Notes
Enhanced tanning / pigmentation Increases melanin production Produces a deeper, longer-lasting tan without excessive UV exposure
Photoprotection Melanin absorbs and dissipates UV radiation May reduce sunburn risk and DNA damage in skin cells
Reduced photosensitivity Helps individuals with light sensitivity disorders Approved for erythropoietic protoporphyria (EPP)
Even skin tone / vitiligo support May help repigment affected areas Early studies show potential synergy with phototherapy
Possible anti-aging effect (indirect) Increased melanin protects against photoaging Helps limit UV-induced oxidative stress and wrinkles